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Molecular Profile SF3B1 V1078A
Therapy E7107
Indication/Tumor Type colorectal cancer
Response Type resistant

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
SF3B1 V1078A colorectal cancer resistant E7107 Preclinical - Cell culture Actionable In a preclinical study, SF3B1 V1078A was identified as a recurrent mutation in colorectal cancer cells acquired resistance to E7107 in culture (PMID: 28541300). 28541300
PubMed Id Reference Title Details
(28541300) Splicing modulators act at the branch point adenosine binding pocket defined by the PHF5A-SF3b complex. Full reference...