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Molecular Profile FGFR2 H167_N173del FGFR2 L617F
Therapy Debio 1347
Indication/Tumor Type intrahepatic cholangiocarcinoma
Response Type predicted - resistant


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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
FGFR2 H167_N173del FGFR2 L617F intrahepatic cholangiocarcinoma predicted - resistant Debio 1347 Case Reports/Case Series Actionable In a clinical study, a patient with intrahepatic cholangiocarcinoma harboring FGFR2 H167_N173del developed resistance to Debio 1347 treatment after initial response, FGFR2 L617F was identified as an acquired mutation at disease progression (J Clin Oncol 38, 2020 (suppl 4; abstr 567)). detail...
PubMed Id Reference Title Details
Therapeutic targeting of extracellular FGFR2 activating deletions in intrahepatic cholangiocarcinoma. Full reference...