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Molecular Profile Unknown unknown
Therapy SRF388
Indication/Tumor Type renal cell carcinoma
Response Type not applicable

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Unknown unknown renal cell carcinoma not applicable SRF388 Preclinical Actionable In a preclinical study, SRF388 treatment demonstrated antitumor activity in an orthotopic mouse model of renal cell carcinoma (AACR 2020, Therapeutic Antibodies 3; PO.IM02.25, Abs nr: 4550/18). detail...
PubMed Id Reference Title Details
Increased IL-27 is associated with poor prognosis in renal cell carcinoma and supports use of SRF388, a first-in-class IL-27p28 blocking antibody, to counteract IL-27-mediated immunosuppression in this setting Full reference...