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Molecular Profile Unknown unknown
Therapy Cytarabine + Onvansertib
Indication/Tumor Type acute myeloid leukemia
Response Type not applicable


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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Unknown unknown acute myeloid leukemia not applicable Cytarabine + Onvansertib Phase I Actionable In a Phase Ib trial, Onvansertib (PCM-075) and low-dose Cytosar-U (cytarabine) combination therapy resulted in an overall response rate of 13% (2/15) in patients with relapsed or refractory acute myeloid leukemia, with 1 patient achieving a complete remission without hematologic recovery, and 25% (3/12) of the evaluable patients achieved a >=50% reduction of bone marrow blasts (PMID: 32998961; NCT03303339). 32998961
PubMed Id Reference Title Details
(32998961) A Phase Ib Study of Onvansertib, a Novel Oral PLK1 Inhibitor, in Combination Therapy for Patients with Relapsed or Refractory Acute Myeloid Leukemia. Full reference...