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Molecular Profile Unknown unknown
Therapy Brequinar
Indication/Tumor Type acute myeloid leukemia
Response Type not applicable


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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Unknown unknown acute myeloid leukemia not applicable Brequinar Preclinical - Pdx & cell culture Actionable In a preclinical study, Brequinar treatment induced differentiation of acute myeloid leukemia cell lines in culture, reduced colony formation of tumor cells, decreased leukemic burden and leukemia initiating cells, and increased survival in syngeneic mouse models, induced differentiation of tumor cells, reduced tumor growth, and increased survival in cell line xenograft models, and induced differentiation of tumor cells and reduced leukemic burden in a patient-derived xenograft (PDX) model (PMID: 27641501). 27641501
PubMed Id Reference Title Details
(27641501) Inhibition of Dihydroorotate Dehydrogenase Overcomes Differentiation Blockade in Acute Myeloid Leukemia. Full reference...