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|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Unknown unknown||acute myeloid leukemia||not applicable||Brequinar||Preclinical - Pdx & cell culture||Actionable||In a preclinical study, Brequinar treatment induced differentiation of acute myeloid leukemia cell lines in culture, reduced colony formation of tumor cells, decreased leukemic burden and leukemia initiating cells, and increased survival in syngeneic mouse models, induced differentiation of tumor cells, reduced tumor growth, and increased survival in cell line xenograft models, and induced differentiation of tumor cells and reduced leukemic burden in a patient-derived xenograft (PDX) model (PMID: 27641501).||27641501|