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Molecular Profile ERBB2 over exp
Therapy Trastuzumab deruxtecan
Indication/Tumor Type gastroesophageal junction adenocarcinoma
Response Type predicted - sensitive

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
ERBB2 over exp gastroesophageal junction adenocarcinoma predicted - sensitive Trastuzumab deruxtecan Phase II Actionable In a Phase II trial (DESTINY-Gastric01), Enhertu (fam-trastuzumab deruxtecan-nxki) treatment improved objective response rate (51%, 61/119 vs 14%, 8/56, p<0.0001) and overall survival (12.5 vs 8.4 mo, HR=0.59, p=0.01) compared to chemotherapy in patients with advanced gastric cancer or gastroesophageal junction adenocarcinoma with high Erbb2 (Her2) expression (IHC 3+ or IHC 2+ plus ISH +), whose disease progressed after 2 or more prior therapies (PMID: 32469182; NCT03329690). 32469182
PubMed Id Reference Title Details
(32469182) Trastuzumab Deruxtecan in Previously Treated HER2-Positive Gastric Cancer. Full reference...