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|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|EML4 - ALK ALK L1196M ALK G1202R||Advanced Solid Tumor||sensitive||TPX-0131||Preclinical - Cell line xenograft||Actionable||In a preclinical study, TPX-0131 inhibited proliferation of transformed cells expressing ALK L1196M and ALK G1202R compound mutation in the context of EML4-ALK in culture, and resulted in complete tumor growth regression in a cell line xenograft model (PMID: 34158340).||34158340|
|EML4 - ALK ALK L1196M ALK G1202R||Advanced Solid Tumor||sensitive||TPX-0131||Preclinical - Cell culture||Actionable||In a preclinical study, TPX-0131 treatment inhibited Alk phosphorylation and viability of transformed cells expressing EML4-ALK with ALK G1202R and L1196M in culture (PMID: 36201110).||36201110|