Profile Response Detail


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Molecular Profile Unknown unknown
Therapy Capivasertib + Enzalutamide
Indication/Tumor Type prostate cancer
Response Type not applicable


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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Unknown unknown prostate cancer not applicable Capivasertib + Enzalutamide Phase I Actionable In a Phase I trial, Capivasertib (AZD5363) and Xtandi (enzalutamide) combination treatment was well-tolerated and demonstrated safety, and resulted in an overall response rate of 25% (3/12) in evaluable metastatic castration-resistant prostate cancer patients (n=16) harboring either a PTEN loss or AKT1 E17K (PMID: 32205016; NCT02525068). 32205016
PubMed Id Reference Title Details
(32205016) A phase I dose-escalation study of enzalutamide in combination with the AKT inhibitor AZD5363 (capivasertib) in patients with metastatic castration-resistant prostate cancer. Full reference...