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|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|PIK3CA amp||lung squamous cell carcinoma||no benefit||Capivasertib||Case Reports/Case Series||Actionable||In a Phase II trial (NLMT), Capivasertib (AZD5363) treatment resulted in no confirmed responses (0/12) and durable clinical benefit in 9% (1/11) of patients with squamous cell lung cancer harboring PIK3CA amplification, thus the cohort was closed due to futility (PMID: 32669708, NCT02664935).||32669708|