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Molecular Profile PTEN loss
Therapy Fluorouracil + Ipatasertib + Leucovorin + Oxaliplatin
Indication/Tumor Type stomach cancer
Response Type sensitive


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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
PTEN loss stomach cancer sensitive Fluorouracil + Ipatasertib + Leucovorin + Oxaliplatin Preclinical - Pdx Actionable In a preclinical study, the combination of Ipatasertib (GDC-0068) and FOLFOX inhibited tumor growth in a patient-derived xenograft (PDX) model of ERBB2 (HER2)-negative gastric cancer harboring PTEN loss, and demonstrated increased activity over either agent alone (PMID: 32205017). 32205017
PubMed Id Reference Title Details
(32205017) Antitumor activity of ipatasertib combined with chemotherapy: results from a phase Ib study in solid tumors. Full reference...