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Molecular Profile Unknown unknown
Therapy Mivebresib
Indication/Tumor Type uveal melanoma
Response Type not applicable

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Unknown unknown uveal melanoma not applicable Mivebresib Phase I Actionable In a Phase I trial, Mivebresib (ABBV-075) treatment demonstrated safety and modest clinical activity in patients with uveal melanoma, resulting in stable disease as best response in 44% (4/9) of evaluable patients, patients achieved stable disease had lower cfDNA mutational load of pathogenic mutations (53.1 vs 893.9 median mutant molecules/mL plasma) compared to patients developed progressive disease (J Clin Oncol 37, no. 15_suppl; NCT02391480). detail...
PubMed Id Reference Title Details
Cell-free DNA in uveal melanoma: Results from the first-in-human trial of mivebresib (ABBV-075). Full reference...