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Molecular Profile NPM1 exon12
Therapy Deguelin
Indication/Tumor Type acute myeloid leukemia
Response Type sensitive


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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
NPM1 exon12 acute myeloid leukemia sensitive Deguelin Preclinical Actionable In preclinical studies, deguelin treatment of an AML cell line harboring NPM1 exon12 mutation resulted in reduced levels of mutant Npm1 protein and induced differentiation of the cells (PMID: 25242579, PMID: 25348016). 25242579 25348016
PubMed Id Reference Title Details
(25242579) Deguelin, a selective silencer of the NPM1 mutant, potentiates apoptosis and induces differentiation in AML cells carrying the NPM1 mutation. Full reference...
(25348016) Nontoxic-dose of deguelin induce NPMc+ AML cell differentiation by selectively targeting Mt NPM1/SIRT1 instead of HDAC1/3. Full reference...