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Molecular Profile | Unknown unknown |
Therapy | Carboplatin + Gemcitabine + Trilaciclib |
Indication/Tumor Type | triple-receptor negative breast cancer |
Response Type | not applicable |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
Unknown unknown | triple-receptor negative breast cancer | not applicable | Carboplatin + Gemcitabine + Trilaciclib | Phase II | Actionable | In a Phase II trial, Trilaciclib (G1T28) in combination with Gemzar (gemcitabine) and Paraplatin (carboplatin) were well tolerated in patients with metastatic triple-negative breast cancer, and resulted in an objective response rate of 43% (26/60, all partial responses), a median overall survival of 20.1 months, and a median progression-free survival of 8.8 months, but did not significantly improve myelosuppression (PMID: 31575503; NCT02978716). | 31575503 |
PubMed Id | Reference Title | Details |
---|---|---|
(31575503) | Trilaciclib plus chemotherapy versus chemotherapy alone in patients with metastatic triple-negative breast cancer: a multicentre, randomised, open-label, phase 2 trial. | Full reference... |