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Molecular Profile SETBP1 mutant
Therapy N/A
Indication/Tumor Type myelodysplastic/myeloproliferative neoplasm
Response Type not applicable


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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
SETBP1 mutant myelodysplastic/myeloproliferative neoplasm not applicable N/A Preclinical Emerging In a preclinical study, SETPB1 missense mutations conferred a predicted gain-of-function, resulting in transformation of murine myeloid progenitors and increased Pp2ac phosphorylation compared to wild-type SETBP1 in culture, suggesting that Setbp1 may serve as a potential therapeutic target (PMID: 23832012). 23832012
PubMed Id Reference Title Details
(23832012) Somatic SETBP1 mutations in myeloid malignancies. Full reference...