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Molecular Profile BRAF D594G
Therapy Sorafenib
Indication/Tumor Type melanoma
Response Type sensitive

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
BRAF D594G melanoma sensitive Sorafenib Preclinical - Cell line xenograft Actionable In a preclinical study, Nexavar (sorafenib) treatment inhibited Erk phosphorylation, reduced growth, and induced mitochondrial depolarization and apoptosis in melanoma cells harboring BRAF D594G in culture, and inhibited tumor growth and induced regression in a cell line xenograft model (PMID: 18794803). 18794803
PubMed Id Reference Title Details
(18794803) CRAF inhibition induces apoptosis in melanoma cells with non-V600E BRAF mutations. Full reference...