Profile Response Detail

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Molecular Profile HRAS G12V HRAS R135K
Therapy NS1
Indication/Tumor Type Advanced Solid Tumor
Response Type resistant

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
HRAS G12V HRAS R135K Advanced Solid Tumor resistant NS1 Preclinical Actionable In a preclinical study, introducing HRAS R135K mutation in transformed cells expressing HRAS G12V resulted in reduced binding of Hras to NS1, leading to resistance to Mapk pathway inhibition in cell culture (PMID: 27820802). 27820802
PubMed Id Reference Title Details
(27820802) Inhibition of RAS function through targeting an allosteric regulatory site. Full reference...