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Molecular Profile CDKN2A hypermethylation
Therapy N/A
Indication/Tumor Type colorectal cancer
Response Type not applicable


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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
CDKN2A hypermethylation colorectal cancer not applicable N/A Clinical Study - Meta-analysis Prognostic In a meta-analysis, CDKN2A promoter hypermethylation was associated with poor overall survival (HR=1.65, 95% CI 1.29-2.11), lymphovascular invasion (OR=1.68, 95% CI 1.15-2.47), and lymph node metastasis (OR=1.68, 95% CI 1.09-2.59) in colorectal cancer patients, and correlated significantly with poor overall survival in patients from Europe (HR=1.49, 95% CI 1.28-1.74) and Asia (HR=3.30, 95% CI 1.68-6.46) (PMID: 23703248). 23703248
PubMed Id Reference Title Details
(23703248) The prognostic value of CDKN2A hypermethylation in colorectal cancer: a meta-analysis. Full reference...