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Molecular Profile KIT exon13
Therapy Adavosertib + Avapritinib
Indication/Tumor Type gastrointestinal stromal tumor
Response Type sensitive


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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
KIT exon13 gastrointestinal stromal tumor sensitive Adavosertib + Avapritinib Preclinical - Cell culture Actionable In a preclinical study, the combination of Adavosertib (MK-1775) and Ayvakit (avapritinib) synergized to inhibit growth of a gastrointestinal stromal tumor cell line harboring a KIT exon 13 mutation in culture (PMID: 33320833). 33320833
PubMed Id Reference Title Details
(33320833) Identification of Wee1 as target in combination with avapritinib for Gastrointestinal Stromal Tumor treatment. Full reference...