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Molecular Profile | Unknown unknown |
Therapy | CRLX101 + Paclitaxel |
Indication/Tumor Type | fallopian tube cancer |
Response Type | not applicable |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
Unknown unknown | fallopian tube cancer | not applicable | CRLX101 + Paclitaxel | Phase Ib/II | Actionable | In a Phase Ib/II trial, CRLX101 in combination with weekly Taxol (paclitaxel) resulted in an objective response rate (ORR) of 31.6% (6/19, 1 complete response, 5 partial responses) and a median progression-free survival of 5.4 months in patients with recurrent or persistent epithelial ovarian, fallopian tube, or primary peritoneal cancer, although the ORR was not superior to that of historical control (PMID: 33390325; NCT02389985). | 33390325 |
PubMed Id | Reference Title | Details |
---|---|---|
(33390325) | A phase Ib/II and pharmacokinetic study of EP0057 (formerly CRLX101) in combination with weekly paclitaxel in patients with recurrent or persistent epithelial ovarian, fallopian tube, or primary peritoneal cancer. | Full reference... |