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Molecular Profile KIT V560_Y578del
Therapy Copanlisib + Imatinib
Indication/Tumor Type gastrointestinal stromal tumor
Response Type sensitive


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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
KIT V560_Y578del gastrointestinal stromal tumor sensitive Copanlisib + Imatinib Preclinical - Cell line xenograft Actionable In a preclinical study, the combination of Aliqopa (copanlisib) and Gleevec (imatinib) demonstrated enhanced cell growth inhibition and increased apoptosis of gastrointestinal stromal tumor cells harboring KIT V560_Y578del in culture and in cell line xenograft models (PMID: 32371592). 32371592
PubMed Id Reference Title Details
(32371592) Preclinical Activity of PI3K Inhibitor Copanlisib in Gastrointestinal Stromal Tumor. Full reference...