Profile Response Detail

Molecular Profile APC inact mut
Therapy ICG-001
Indication/Tumor Type colon cancer
Response Type sensitive
Create By cstatz
Update By smockus


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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
APC inact mut colon cancer sensitive ICG-001 Preclinical Actionable In a preclinical study, ICG-001 decreased cell proliferation in colon cancer cell lines and in mouse models carrying APC inactivating mutations (PMID: 15314234). 15314234
PubMed Id Reference Title Details
(15314234) A small molecule inhibitor of beta-catenin/CREB-binding protein transcription [corrected]. Full reference...