Profile Response Detail

Molecular Profile APC inact mut
Therapy PKF115-584
Indication/Tumor Type colon cancer
Response Type sensitive
Create By cstatz
Update By spatterson


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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
APC inact mut colon cancer sensitive PKF115-584 Preclinical Actionable In a preclinical study, PKF115-584 inhibited proliferation of colorectal cancer cell line harboring an APC inactivating mutation in culture (PMID: 14749129). 14749129
PubMed Id Reference Title Details
(14749129) Small-molecule antagonists of the oncogenic Tcf/beta-catenin protein complex. Full reference...