Profile Response Detail

Molecular Profile RET C634R
Therapy Sorafenib
Indication/Tumor Type Advanced Solid Tumor
Response Type sensitive
Create By spatterson
Update By spatterson

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
RET C634R Advanced Solid Tumor sensitive Sorafenib Preclinical Actionable In a preclinical study, Nexavar (sorafenib) inhibited RET kinase activity and proliferation in transformed cells expressing RET C634R in culture (PMID: 16507829). 16507829
RET C634R Advanced Solid Tumor sensitive Sorafenib Preclinical Actionable In a preclinical study, Nexavar (sorafenib) inhibited RET phosphorylation and decreased growth of cells expressing RET C634R in culture (PMID: 17664273). 17664273
PubMed Id Reference Title Details
(17664273) Sorafenib functions to potently suppress RET tyrosine kinase activity by direct enzymatic inhibition and promoting RET lysosomal degradation independent of proteasomal targeting. Full reference...
(16507829) BAY 43-9006 inhibition of oncogenic RET mutants. Full reference...