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Molecular Profile Unknown unknown
Therapy Buparlisib
Indication/Tumor Type triple-receptor negative breast cancer
Response Type no benefit


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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Unknown unknown triple-receptor negative breast cancer no benefit Buparlisib Phase II Actionable In a Phase II trial, Buparlisib (BKM120) treatment in patients with triple-negative breast cancer (TNBC) resulted in median progression-free survival of 1.8 months, median overall survival of 11.2 months, stable disease lasting more than four months in 12% (6/50) of patients, and no objective responses, and due to the limited clinical efficacy, further study as a single agent in TNBC patients was not supported (PMID: 33138866; NCT01790932, NCT01629615). 33138866
PubMed Id Reference Title Details
(33138866) Phase 2 study of buparlisib (BKM120), a pan-class I PI3K inhibitor, in patients with metastatic triple-negative breast cancer. Full reference...