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|Molecular Profile||FGFR2 act mut|
|Indication/Tumor Type||stomach carcinoma|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|FGFR2 act mut||stomach carcinoma||sensitive||S-49076||Preclinical - Cell line xenograft||Actionable||In a preclinical study, S-49076 inhibited Met activation, resulting in growth inhibition of gastric carcinoma cells harboring FGFR2 activating mutations in culture and in cell line xenograft models (PMID: 23804704).||23804704|
|PubMed Id||Reference Title||Details|
|(23804704)||S49076 is a novel kinase inhibitor of MET, AXL, and FGFR with strong preclinical activity alone and in association with bevacizumab.||Full reference...|