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Molecular Profile BRAF V600E
Therapy Dabrafenib + Regorafenib + Trametinib
Indication/Tumor Type colon adenocarcinoma
Response Type predicted - sensitive


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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
BRAF V600E colon adenocarcinoma predicted - sensitive Dabrafenib + Regorafenib + Trametinib Case Reports/Case Series Actionable In a clinical case study, combination treatment with Stivarga (regorafenib), Tafinlar (dabrafenib), and Mekinist (trametinib) in a patient with colon adenocarcinoma harboring BRAF V600E led to stable disease, and treatment continued for eight months, at which time some disease progression was observed (PMID: 33568355). 33568355
PubMed Id Reference Title Details
(33568355) Exploiting allosteric properties of RAF and MEK inhibitors to target therapy-resistant tumors driven by oncogenic BRAF signaling. Full reference...