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|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|PALB2 L1027R||Advanced Solid Tumor||sensitive||Olaparib||Preclinical - Cell culture||Actionable||In a preclinical study, expressing PALB2 L1027R conferred sensitivity to Lynparza (olaparib)-induced growth inhibition in TP53 and PALB2 double knock-out mouse embryonic stem cells in culture (PMID: 33811135).||33811135|