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Molecular Profile | PALB2 L1027R |
Therapy | Olaparib |
Indication/Tumor Type | Advanced Solid Tumor |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
PALB2 L1027R | Advanced Solid Tumor | sensitive | Olaparib | Preclinical - Cell culture | Actionable | In a preclinical study, expressing PALB2 L1027R conferred sensitivity to Lynparza (olaparib)-induced growth inhibition in TP53 and PALB2 double knock-out mouse embryonic stem cells in culture (PMID: 33811135). | 33811135 |
PubMed Id | Reference Title | Details |
---|---|---|
(33811135) | Characterisation of protein-truncating and missense variants in PALB2 in 15 768 women from Malaysia and Singapore. | Full reference... |