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Molecular Profile | ATRX loss |
Therapy | Talazoparib |
Indication/Tumor Type | high grade glioma |
Response Type | predicted - sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
ATRX loss | high grade glioma | predicted - sensitive | Talazoparib | Preclinical - Cell culture | Actionable | In a preclinical study, Talzenna (talazoparib) treatment inhibited viability of immortalized astrocytes with loss of ATRX in culture (PMID: 34118569). | 34118569 |
PubMed Id | Reference Title | Details |
---|---|---|
(34118569) | Loss of ATRX confers DNA repair defects and PARP inhibitor sensitivity. | Full reference... |