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Molecular Profile MAP2K1 Q56P MAP2K1 H119Y MAP2K1 D351G
Therapy LY3214996
Indication/Tumor Type colorectal cancer
Response Type predicted - sensitive


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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
MAP2K1 Q56P MAP2K1 H119Y MAP2K1 D351G colorectal cancer predicted - sensitive LY3214996 Preclinical - Cell line xenograft Actionable In a preclinical study, LY3214996 treatment in a colorectal cancer cell line harboring MAP2K1 Q56P, MAP2K1 H119Y, and MAP2K1 D351G led to decreased cell proliferation in culture, and inhibition of tumor growth in a cell line xenograft model (PMID: 31744895). 31744895
PubMed Id Reference Title Details
(31744895) ERK Inhibitor LY3214996 Targets ERK Pathway-Driven Cancers: A Therapeutic Approach Toward Precision Medicine. Full reference...