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Molecular Profile BRAF V600E
Therapy Dabrafenib + Rabeprazole + Rifampin + Trametinib
Indication/Tumor Type endometrial adenocarcinoma
Response Type predicted - sensitive

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
BRAF V600E endometrial adenocarcinoma predicted - sensitive Dabrafenib + Rabeprazole + Rifampin + Trametinib Case Reports/Case Series Actionable In a Phase I trial, the addition of Mekinist (trametinib) to combination treatment with Tafinlar (dabrafenib), Rabeprazole, and Rifampin resulted in a maintained radiographic response of lung metastases and stable pelvic mass size in a patient with metastatic endometrial adenocarcinoma harboring BRAF V600E, which lasted for 12 months (PMID: 33537843; NCT01954043). 33537843
PubMed Id Reference Title Details
(33537843) BRAF/MEK inhibitors for BRAF V600E-mutant cancers in non-approved setting: a case series. Full reference...