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|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|KMT2A - AFF4||leukemia||predicted - sensitive||Tranylcypromine + Tretinoin||Preclinical - Cell culture||Actionable||In a preclinical study, the addition of Parnate (tranylcypromine) resulted in increased sensitivity to Vesanoid (tretinoin) treatment in a murine leukemic cell line harboring a KMT2A-AFF4 fusion (also known as MLL-AF5q31), with inhibition of cell growth and CD11b expression in culture (Blood (2012) 120 (21): 1345.).||detail...|
|PubMed Id||Reference Title||Details|
|LSD1 Inhibitor Activates Retinoic Acid Pathway in MLL Fusion Positive Acute Myeloid Leukemia||Full reference...|