Profile Response Detail


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Molecular Profile KMT2A - AFF4
Therapy Tranylcypromine + Tretinoin
Indication/Tumor Type leukemia
Response Type predicted - sensitive


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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
KMT2A - AFF4 leukemia predicted - sensitive Tranylcypromine + Tretinoin Preclinical - Cell culture Actionable In a preclinical study, the addition of Parnate (tranylcypromine) resulted in increased sensitivity to Vesanoid (tretinoin) treatment in a murine leukemic cell line harboring a KMT2A-AFF4 fusion (also known as MLL-AF5q31), with inhibition of cell growth and CD11b expression in culture (Blood (2012) 120 (21): 1345.). detail...
PubMed Id Reference Title Details
LSD1 Inhibitor Activates Retinoic Acid Pathway in MLL Fusion Positive Acute Myeloid Leukemia Full reference...