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Molecular Profile MLH1 negative
Therapy Dostarlimab-gxly
Indication/Tumor Type rectum cancer
Response Type sensitive

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
MLH1 negative rectum cancer sensitive Dostarlimab-gxly Phase II Actionable In a Phase II trial, neoadjuvant Jemperli (dostarlimab-gxly) treatment resulted in an objective response of 100% (12/12, all complete responses) in patients with stage II or III rectal cancer with deficient mismatch repair (dMMR) as defined by the loss of MLH1, PMS2, MSH2, or MSH6 expression by IHC (PMID: 35660797; NCT04165772). 35660797
MLH1 negative rectum cancer sensitive Dostarlimab-gxly Guideline Actionable Jemperli (dostarlimab-gxly) is included in guidelines as subsequent therapy for patients with advanced or metastatic rectal cancer with high microsatellite instability (MSI-H) or deficient mismatch repair (dMMR, often defined by the loss of MLH1, PMS2, MSH2, or MSH6 expression by IHC) (NCCN.org). detail...
PubMed Id Reference Title Details
NCCN.org Full reference...
(35660797) PD-1 Blockade in Mismatch Repair-Deficient, Locally Advanced Rectal Cancer. Full reference...