Profile Response Detail


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Molecular Profile MAP2K1 F53C
Therapy Vemurafenib
Indication/Tumor Type lymphoma
Response Type predicted - resistant


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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
MAP2K1 F53C lymphoma predicted - resistant Vemurafenib Preclinical - Cell culture Actionable In a preclinical study, expression of MAP2K1 F53C in a lymphoma cell line conferred resistance to inhibition of Erk phosphorylation by Zelboraf (vemurafenib) in culture (PMID: 30341394). 30341394
PubMed Id Reference Title Details
(30341394) Targeting MEK in vemurafenib-resistant hairy cell leukemia. Full reference...