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|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|FGFR2 - DDX21 FGFR2 K659M FGFR2 Y779C||cholangiocarcinoma||predicted - resistant||Debio 1347||Case Reports/Case Series||Actionable||In a clinical case study, a patient with cholangiocarcinoma harboring an FGFR2-DDX21 fusion experienced disease progression after 5.5 months of treatment with Debio 1347 and was found to have acquired additional FGFR2 mutations, K659M and Y779C (PMID: 34250419).||34250419|