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Molecular Profile FGFR2 - DDX21 FGFR2 K659M FGFR2 Y779C
Therapy Debio 1347
Indication/Tumor Type cholangiocarcinoma
Response Type predicted - resistant


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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
FGFR2 - DDX21 FGFR2 K659M FGFR2 Y779C cholangiocarcinoma predicted - resistant Debio 1347 Case Reports/Case Series Actionable In a clinical case study, a patient with cholangiocarcinoma harboring an FGFR2-DDX21 fusion experienced disease progression after 5.5 months of treatment with Debio 1347 and was found to have acquired additional FGFR2 mutations, K659M and Y779C (PMID: 34250419). 34250419
PubMed Id Reference Title Details
(34250419) Noninvasive Detection of Polyclonal Acquired Resistance to FGFR Inhibition in Patients With Cholangiocarcinoma Harboring FGFR2 Alterations. Full reference...