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Molecular Profile BRAF V600E
Therapy Cobimetinib + Gemcitabine + Nab-paclitaxel
Indication/Tumor Type pancreatic ductal adenocarcinoma
Response Type predicted - sensitive

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
BRAF V600E pancreatic ductal adenocarcinoma predicted - sensitive Cobimetinib + Gemcitabine + Nab-paclitaxel Case Reports/Case Series Actionable In a clinical case study, Gemzar (gemcitabine), Abraxane (nab-paclitaxel), and Cotellic (cobimetinib) combination treatment resulted in a complete radiologic response within 6 months of initiation lasting at least 16 months in a patient with microsatellite stable, KRAS wild-type pancreatic ductal adenocarcinoma harboring BRAF V600E (PMID: 34667063). 34667063
PubMed Id Reference Title Details
(34667063) Potential benefit of treatment with MEK inhibitors and chemotherapy in BRAF-mutated KRAS wild-type pancreatic ductal adenocarcinoma patients: a case report. Full reference...