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Molecular Profile Unknown unknown
Therapy Fluorouracil + Irinotecan + Leucovorin + Ramucirumab
Indication/Tumor Type colorectal cancer
Response Type not applicable

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Unknown unknown colorectal cancer not applicable Fluorouracil + Irinotecan + Leucovorin + Ramucirumab FDA approved Actionable In a Phase III trial (RAISE) that supported FDA approval, treatment with a combination of Cyramza (ramucirumab) and the FOLFIRI chemotherapy regimen improved median overall survival (13.3 vs 11.7 mo, HR=0.844, p=0.0219) in patients with metastatic colorectal cancer (PMID: 25877855; NCT01183780). 25877855 detail...
PubMed Id Reference Title Details
(25877855) Ramucirumab versus placebo in combination with second-line FOLFIRI in patients with metastatic colorectal carcinoma that progressed during or after first-line therapy with bevacizumab, oxaliplatin, and a fluoropyrimidine (RAISE): a randomised, double-blind, multicentre, phase 3 study. Full reference...
Cyramza (ramucirumab) FDA Drug Label Full reference...