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Molecular Profile ERBB3 over exp
Therapy Patritumab deruxtecan
Indication/Tumor Type prostate cancer
Response Type sensitive

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
ERBB3 over exp prostate cancer sensitive Patritumab deruxtecan Preclinical - Pdx & cell culture Actionable In a preclinical study, Patritumab deruxtecan (U3-1402) inhibited growth of patient-derived prostate cancer cells with high ERBB3 (HER3) expression in culture and in a patient-derived xenograft (PDX) model, but did not demonstrate anti-tumor activity in cell lines with low ERBB3 (HER3) expression (PMID: 34753775). 34753775
PubMed Id Reference Title Details
(34753775) HER3 Is an Actionable Target in Advanced Prostate Cancer. Full reference...