Profile Response Detail


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Molecular Profile MDM2 amp
Therapy BI 907828
Indication/Tumor Type liposarcoma
Response Type predicted - sensitive


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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
MDM2 amp liposarcoma predicted - sensitive BI 907828 Case Reports/Case Series Actionable In a Phase I trial, BI 907828 treatment led to a partial response in 3 of 7 patients with liposarcoma, all responders harbored MDM2 amplification (Ann Oncol 32 (2021): S1294; NCT03449381). detail...
PubMed Id Reference Title Details
1548P A phase Ia/Ib, dose-escalation/expansion study of the MDM2–p53 antagonist BI 907828 in patients (pts) with advanced/metastatic sarcoma Full reference...