Missing content? – Request curation!
Request curation for specific Genes, variants, or PubMed publications.
Have questions, comments or suggestions? - Let us know!
Email us at : ckbsupport@jax.org
Molecular Profile | FGFR3 - TACC3 |
Therapy | Debio 1347 |
Indication/Tumor Type | central nervous system cancer |
Response Type | predicted - sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
FGFR3 - TACC3 | central nervous system cancer | predicted - sensitive | Debio 1347 | Case Reports/Case Series | Actionable | In a clinical case study, Debio 1347 treatment resulted in a prolonged stable disease and stable clinical symptoms at 26 months in a pediatric patient with a right cerebellar hemispheric rosette-forming glioneuronal tumor harboring an FGFR3-TACC3 fusion (PMID: 34250399). | 34250399 |
PubMed Id | Reference Title | Details |
---|---|---|
(34250399) | Debio1347, an Oral FGFR Inhibitor: Results From a Single-Center Study in Pediatric Patients With Recurrent or Refractory FGFR-Altered Gliomas. | Full reference... |