Profile Response Detail


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Molecular Profile BRAF class 2
Therapy Exarafenib
Indication/Tumor Type pancreatic cancer
Response Type predicted - sensitive


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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
BRAF class 2 pancreatic cancer predicted - sensitive Exarafenib Preclinical - Cell culture Actionable In a preclinical study, Exarafenib (KIN-2787) treatment led to inhibition of tumor growth in a pancreatic cell line xenograft model harboring a BRAF class 2 mutation (J of Clin Oncol 39, no. 15_suppl (May 20, 2021) 3116-3116). detail...
PubMed Id Reference Title Details
The next-generation pan-RAF inhibitor, KIN-2787, is active in class II and class III BRAF mutant models. Full reference...