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Molecular Profile | BRAF V600E NRAS Q61K |
Therapy | Vemurafenib |
Indication/Tumor Type | melanoma |
Response Type | resistant |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
BRAF V600E NRAS Q61K | melanoma | resistant | Vemurafenib | Preclinical | Actionable | In a preclinical study, a NRAS Q61K mutation conferred resistance to Zelboraf (vemurafenib) in melanoma cells harboring BRAF V600E in culture (PMID: 21107323). | 21107323 |
PubMed Id | Reference Title | Details |
---|---|---|
(21107323) | Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation. | Full reference... |