Profile Response Detail


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Molecular Profile ATM S1905Ifs*25
Therapy Olaparib
Indication/Tumor Type gallbladder carcinoma
Response Type predicted - sensitive


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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
ATM S1905Ifs*25 gallbladder carcinoma predicted - sensitive Olaparib Case Reports/Case Series Actionable In a clinical case study, treatment with Lynparza (olaparib) resulted in improved clinical symptoms and progression-free survival of 13 months in a patient with gallbladder carcinoma harboring ATM S1905Ifs*25 (PMID: 32045060). 32045060
PubMed Id Reference Title Details
(32045060) Effectiveness of Olaparib Treatment in a Patient with Gallbladder Cancer with an ATM-Inactivating Mutation. Full reference...