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Molecular Profile IDH1 R132S
Therapy Ceralasertib + Olaparib
Indication/Tumor Type cholangiocarcinoma
Response Type sensitive

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
IDH1 R132S cholangiocarcinoma sensitive Ceralasertib + Olaparib Preclinical - Cell culture Actionable In a preclinical study, the combination of Lynparza (olaparib) and Ceralasertib (AZD6738) resulted in a greater decrease in cell viability compared to Ceralasertib (AZD6738) alone in cholangiocarcinoma cells harboring IDH1 R132S in culture (PMID: 34027408). 34027408
PubMed Id Reference Title Details
(34027408) Targeting IDH1/2 mutant cancers with combinations of ATR and PARP inhibitors. Full reference...