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|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|PIK3CA mutant||Advanced Solid Tumor||sensitive||BAY1082439||Preclinical||Actionable||In a preclinical study, BAY1082439 induced regression in xenograft models of advanced solid tumors with PIK3CA mutations (Cancer Res April 15, 2012 72; 2799).||detail...|
|PubMed Id||Reference Title||Details|
|Abstract 2799: BAY 1082439, a highly selective and balanced PI3Kalpha/beta inhibitor demonstrated potent activity in tumors with activated PI3Kalpha and loss-of-function of PTEN||Full reference...|