Profile Response Detail


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Molecular Profile PIK3CA mutant
Therapy Temsirolimus
Indication/Tumor Type breast cancer
Response Type no benefit


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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
PIK3CA mutant breast cancer no benefit Temsirolimus Phase II Actionable In a Phase II trial, Torisel (temsirolimus) treatment resulted in stable disease in 9.7% (3/31) of breast cancer patients positive for ER, PR or ERBB2 (HER2), however there was no association between PIK3CA mutational status and clinical benefits (PMID: 22245973). 22245973
PubMed Id Reference Title Details
(22245973) Phase II trial of temsirolimus in patients with metastatic breast cancer. Full reference...