Profile Response Detail


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Molecular Profile CTNNB1 G34R
Therapy Everolimus + Sorafenib
Indication/Tumor Type hepatocellular carcinoma
Response Type predicted - sensitive


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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
CTNNB1 G34R hepatocellular carcinoma predicted - sensitive Everolimus + Sorafenib Case Reports/Case Series Actionable In a clinical case study, Afinitor (everolimus) and Nexavar (sorafenib) combination therapy resulted in a 50% tumor response after 3 months of treatment in a patient with metastatic hepatocellular carcinoma harboring CTNNB1 G34R whose disease progressed on prior Nexavar (sorafenib) monotherapy, and the response was ongoing at 8 months (PMID: 20347502). 20347502
PubMed Id Reference Title Details
(20347502) Personalized molecular targeted therapy in advanced, recurrent hepatocellular carcinoma after liver transplantation: a proof of principle. Full reference...