Profile Response Detail

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Molecular Profile PIK3CA E545K
Therapy GDC-0077
Indication/Tumor Type breast cancer
Response Type sensitive

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
PIK3CA E545K breast cancer sensitive GDC-0077 Preclinical - Cell line xenograft Actionable In a preclinical study, GDC-0077 treatment led to tumor regression in an ESR1 (ER)-positive breast cancer cell line xenograft model harboring PIK3CA E545K (PMID: 34544753). 34544753
PubMed Id Reference Title Details
(34544753) RTK-Dependent Inducible Degradation of Mutant PI3Kα Drives GDC-0077 (Inavolisib) Efficacy. Full reference...