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|Molecular Profile||FGFR2 amp|
|Indication/Tumor Type||stomach carcinoma|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|FGFR2 amp||stomach carcinoma||sensitive||CPL304110||Preclinical - Cell line xenograft||Actionable||In a preclinical study, CPL304110 treatment inhibited downstream signaling and proliferation of a gastric carcinoma cell line harboring FGFR2 amplification in culture and inhibited tumor growth in cell line xenograft models (PMID: 33199155).||33199155|
|PubMed Id||Reference Title||Details|
|(33199155)||Discovery and optimization of novel pyrazole-benzimidazole CPL304110, as a potent and selective inhibitor of fibroblast growth factor receptors FGFR (1-3).||Full reference...|