Profile Response Detail

Molecular Profile KRAS exon 2
Therapy Irinotecan + Selumetinib
Indication/Tumor Type colorectal cancer
Response Type predicted - sensitive
Create By smockus
Update By djd

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
KRAS exon 2 colorectal cancer predicted - sensitive Irinotecan + Selumetinib Phase II Actionable In a Phase II study, Selumetinib (AZD6244), in combination with Camptosar (irinotecan), resulted in a partial response in 9.7% (3/31) and stable disease in 51.6% (16/31) of colorectal cancer patients with KRAS exon 2 mutations (PMID: 25322874). 25322874
PubMed Id Reference Title Details
(25322874) Phase II study of selumetinib (AZD6244, ARRY-142886) plus irinotecan as second-line therapy in patients with K-RAS mutated colorectal cancer. Full reference...