Profile Response Detail

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Molecular Profile Unknown unknown
Therapy Ipilimumab
Indication/Tumor Type melanoma
Response Type not applicable

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Unknown unknown melanoma not applicable Ipilimumab FDA approved Actionable In a Phase III trial that supported FDA approval, treatment with Yervoy (ipilimumab) resulted in an improved overall survival of 10.1 months in patients with metastatic melanoma, compared to 6.4 months in those treated with gp100 peptide vaccine alone (PMID: 20525992, PMID: 21900389). 20525992 detail... 21900389
Unknown unknown melanoma not applicable Ipilimumab Phase III Actionable In a Phase III trial, adjuvant Opdivo (nivolumab) treatment resulted in improved rate of recurrence-free survival at 12-months compared to Yervoy (ipilimumab) (70.5% vs 60.8%, HR=0.65, P<0.001) in patients with resected stage III or IV melanoma (PMID: 28891423, NCT02388906). 28891423
PubMed Id Reference Title Details
(21900389) Ipilimumab: an anti-CTLA-4 antibody for metastatic melanoma. Full reference...
(20525992) Improved survival with ipilimumab in patients with metastatic melanoma. Full reference...
(28891423) Adjuvant Nivolumab versus Ipilimumab in Resected Stage III or IV Melanoma. Full reference...
Yervoy (ipilimumab) FDA Drug Label Full reference...